Kainate receptors in the developing neuronal networks
نویسندگان
چکیده
منابع مشابه
Kainate receptors: multiple roles in neuronal plasticity.
Ionotropic glutamate receptors of the N-methyl-d-aspartate (NMDA)- and AMPA-type, as well as metabotropic glutamate receptors have been extensively invoked in plasticity. Until relatively recently, however, kainate-type receptors (KARs) had been the most elusive to study because of the lack of appropriate pharmacological tools to specifically address their roles. With the development of selecti...
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Exogenous kainate receptor agonists have been shown to modulate inhibitory synaptic transmission in the hippocampus, but the pathways involved in physiological activation of the receptors remain largely unknown. Accumulating evidence indicates that astrocytes can release glutamate in a Ca(2+)-dependent manner and signal to neighboring neurons. We tested the hypothesis that astrocyte-derived glu...
متن کاملFunctional diversity and developmental changes in rat neuronal kainate receptors.
1. Whole-cell currents evoked by kainate and the GluR5-selective agonist (RS)-2-amino-3-(3-hydroxy-5-tertbutylisoxazol-4-yl)propanoic acid (ATPA) were used to compare the physiological properties of kainate receptors expressed by neurons from rat hippocampus, spinal cord and dorsal root ganglia. 2. In contrast to kainate, which evoked desensitizing currents with similar decay rates and steady-s...
متن کاملKainate-type Glutamate Receptors Modulating Network Activity in Developing Hippocampus
viii 1 Review of the literature 1 1.2 Development of hippocampal network 2 1.3 Properties of kainate receptors 5 1.3.1 Structure 5 1.3.3 Pharmacology 10 1.3.2 Signaling 8 1.4 Kainate receptors in immature hippocampus 12 1.4.1 Expression 12 1.4.2 Functions 14 1.4.3 Role in network activity 18 1.5 Ethanol and the developing hippocampus 21 2 Aims 24 3 Materials and methods 25 3.1 Preparation of ac...
متن کاملSynaptic drive at developing synapses: transient upregulation of kainate receptors.
At the onset of a period of intense synaptic refinement initiated by synchronized eye opening (EO), rapid changes in postsynaptic NMDA receptor and AMPA receptor currents (NMDARcs and AMPARcs) occur within the superficial visual layers of the rodent superior colliculus (sSC; Lu and Constantine-Paton [2004]: Neuron 43:237-249). Subsequently, evoked non-NMDARc amplitudes increase, but by 2 weeks ...
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ژورنال
عنوان ژورنال: Neuropharmacology
سال: 2021
ISSN: 0028-3908
DOI: 10.1016/j.neuropharm.2021.108585